Prosec/Prosec IV Description

Prosec: Each capsule contains Omeprazole BP 20 mg as enteric coated pellets.
Omeprazole (Prosec), the substituted benzimadole, is an inhibitor of gastric acid secretion. Omeprazole does not exhibit anticholinergic or H₂-histamine antagonistic properties, but inhibits the secretion of gastric acid by blocking the H⁺/K⁺ATPase (hydrogen-potassium-adenosine triphosphatase) enzyme system, the so-called "proton pump" of the gastric parietal cell.
After oral administration of Omeprazole (Prosec) absorption is rapid, onset occurs within 1 hour and peaks within 2 hours.
Inhibition of secretion is about 50% of maximum at 24 hours, and the duration of inhibition lasts not longer than 72 hours.
The antisecretory effect thus lasts far longer than would be expected from the very short (<1 hour) plasma half-life, apparently due to prolonged binding to the parietal H⁺K⁺ATPase enzyme. When the drug is discontinued, secretory activity return over 3 to 5 days.
Prosec IV: Each vial contains sterile powder of Omeprazole (as sodium) BP equivalent to 40 mg Omeprazole.
Each ampoule contains 10 mL of Sterile Water for Injection BP for reconstitution.
Omeprazole (PROSEC), the substituted benzimidazole, is an inhibitor of gastric acid secretion. Omeprazole does not exhibit anticholinergic or H₂-histamine antagonistic properties, but inhibits the secretion of gastric acid by blocking the H⁺/K⁺ATPase (hydrogen-potassium adenosine triphosphatase) enzyme system, the so-called "proton pump" of the gastric parietal cell.